The CW has released an official description of the episode “6.14 – Mannequin 3: The Reckoning“.
which airs Friday, February 18th, 2011. (Warning: Episode Spoilers ahead!)

DEAN RUSHES HOME TO CHECK ON LISA — Ben (guest star Nicolas Elia) calls Dean (Jensen Ackles) and tells him Lisa (guest star Cindy Sampson) is in trouble. Dean leaves Sam (Jared Padalecki) to investigate a case alone and rushes home to rescue Lisa, however, he’s not prepared for what meets him at the door. Meanwhile, Sam discovers the men that were murdered were all a part of a cruel practical joke played on a female co-worker who went missing.

Directed by: Jeannot Szwarc
Written by: Eric Charmelo & Nicole Snyder

Source: The CW