The CW has released an official description of the episode “6.12 – Like a Virgin“.
which airs Friday, February 4th, 2011. (Warning: Episode Spoilers ahead!)

DEATH RETURNS FOR A MEETING WITH DEAN — Dean (Jensen Ackles) and Bobby (Jim Beaver) anxiously wait for Sam (Jared Padalecki) to wake up to see if Death (guest star Julian Richings) was able to restore his soul without causing Sam to lose his mind. Meanwhile, Dean and Bobby investigate a disappearance of virgins and discover dragons are behind the kidnappings. Bobby sends Dean to a doctor who owns the only weapon in the world that can slay a dragon, but Dean must prove himself worthy enough to take it.

Directed by: Phil Sgriccia
Written by: Adam Glass

Source: The CW